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GC00008

来源: 作者: 发布时间: 2021-05-08 393 次浏览

Accession No

GC00009

Strain Name

SD.Lepr(tm)-GC/ILAS

Status

Live

Gene/full name

Lepr / leptin receptor

Gene ID

24536

Background

Sprague Dawley

Type

Knockout

Donor

Lianfeng Zhang, Yuanwu, Dan Bao ,Feifei Guan,Zhang, Xu Zhang, Wei Chen

Disease & Phenotype

lipid metabolismobesity, diabetes 

 

Construction Description

Genotyping Protocols

Lepr-S1GTTTACTAGACACGGATTCAGCAC  

Lepr-AS1AATGGAAACGCTTTGCTGAATG

 

Mating System

Heterozygote x Heterozygote;

Homozygote is infertile

Reference

 

  1. 1.Dan Bao,Yuanwu Ma,Xu Zhang. Preliminary Characterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9 System, Sci Rep. 2015; 5: 15942.